However, a significant question remains about whether these associations represent predisposing features for the risk of developing cigarette smoking or are consequences of cigarette smoking. Specifically, they looked over data on health behaviors, brain scans, and genetic risk factors, all drawn from the dataset known as the UK Biobank, and then performed statistical analysis to see if daily smoking led to decreased brain volume over time
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For instance, chronic cigarette smoke exposure altered the cecal microbiome, reducing microbial diversity and decreasing Alistipes abundance, a genus positively associated with body weight